Medical pharmacology, Jessenius Medical School, Comenius University, Slovakia

Contact: Gabriela Nos  ov , Professor of Pharmacology, Department of Pharmacology, Jessenius Medical School, Comenius University, 037 53 Martin, Sklabinska 26, Slovakia. tel 00421 842 32535; fax 00421 842 34807; email nosalova@doktorjfmed.uniba.sk.

Lectures - 6th term - 26 hours

1. General aspect of pharmacology. Definition and scope of pharmacology. Meaning of materia medica. Sources of drugs. Some common abbreviations and their meanings.
2. Solid and liquid drugs and effects of drugs. Therapeutic methods. Stimulants and depressants.
3. Intimate study of drug action I. Absorption.
4. Intimate study of drug action II. Distribution and elimination.
5. Intimate study of drug action III. Possible mechanisms of drug action.
6. Drugs affecting the digestive system I.
7. Drugs affecting the digestive system II.
8. Drugs affecting the respiratory system.
9. Drugs affecting the excretory system.
10. Agents used in hyperlipaemia.
11. Narcotic analgesics. Drug abuse and dependence.
12. Pharmacology of general anaesthesia.
13. Imunosuppressive agents.

Practical lessons - 6th term - 12 hours
1. Introduction to the problem of prescribing of drugs. The prescribtion - the structure, its single parts. Pharmacopeia - the structure. Narcotic act and rules of prescribing of opiates.
2. The prescribing of brand products and antibiotics.
3. The test - prescribing of brand products.
4. The prescribing of liquid forms of remedies for internal and external use.
5. The prescribing of solid and soft forms of remedies.
6. The test - prescribing of liquid, solid and soft forms of remedies.

Group discussions - 6th term - 14 hours
1. >Hormones of the adrenal, pituitary and gonads.
2. Pancreatic hormones and antidiabetic drugs. Thyroid and antithyroid drugs.
3. Autacoids, hepatoprotective drugs.
4. Antiseptics, disinfectants.
5. Antihelmintics and antimalarial drugs.
6. Written exam in special pharmaclogy.
7. Compensatory lessons and credit.

Lectures - 7th term - 26 hours
1. Drug effects on the nervous system and neuroeffectors; - cholinergic drugs; - cholinergic blocking agents
2. Drug effects on the nervous system and neuroeffectors; - adrenergic drugs; - adrenergic blocking agents; - drugs acting on the adrenergic neuron
3. Psychopharmacology; - general concepts of psychopharmacology; - antipsychotic drugs; - antidepressant and antimanic drugs
4. Psychopharmacology; - antianxiety drugs; - hypnotic drugs and alcohol; - central nervous system stimulants
5. Drugs used in cardiovascular disease - digitalis
6. Drugs used in cardiovascular disease - antiarrhytmic drugs
7. Drugs used in cardiovascular disease - antianginal drugs
8. Chemotherapy; - sulphonamides; - quinolones;
9. Antibiotics; - penicilin and other drugs for treatment of gram-positive infections; - aminoglycosides and other drugs used for treatment of gram-negative infections
10. Drugs used for treatment of mycobacterial infections
11. Drugs used for treatment of fungal infections
12. Antiviral agents
13. Drugs used for treatment of amebiasis and other intestinal protozoal infections; Drugs used for treatment of malaria and other extraintestinal protozoal infections; Antihelmintic drugs

Practical lessons - 7th term
5 laboratory practicals - 10 hours; 8 group discussion - 16 hours; 4 written exams
1. The prescribing of drugs - the repetition
2. Drugs with the influence on cholinergic transmision. The effect of pilocarpine and atropine on salivation in mice - practical lesson
3. Drug with the influence on adrenergic transmision
4. Pharmacology of peripheral autonomic system - the test
5. Antiepileptics; The effect of psychoactive drugs on locomotor activity in mice - practical lesson
6. Analgesic-antipyretics, antiphlogistics and antirheumatics; The effect of analgesics on the perception of the pain in mice - practical lesson
7. Pharmacology of central nervous system - the test
8. Local anaesthetics; The effect of local anaesthetics on corneal reflex in rabbit - practical lesson
9. Pharmacology of blood vessels
10. Pharmacology of cardiovascular system - the test
11. Neuromuscular blocking agents; The effect of neuromuscular blocking agents on the cervical muscles tonus in rabbit - practical lesson
12. Antibiotics and chemotherapeutics - the test
13. Compensatory lessons and credit

By the end of the undergraduate course students should be familiar:
1. From general pharmacology with: - pharmacokinetic principles, it means processes after drug administration - resorbtion, distribution, biotransformation and elimination, basic pharmacodynamic processes, it means mechanisms of drug action on molecular level toxicological concepts and dosology, it means single and maximal therapeutic dose, therapeutic range, therapeutic index, LD50, - prescription of remedies, rules and ways how to prescribe brand products and extemporaneous products.
2. From the special pharmacology with: - pharmacological groups of remedies and single drugs from the view of their mechanism of action, indications, contraindications, adverse effects, important interactions, dosage.

Clinical pharmacology - 10th term - compulsory optional course - 24 hours
1. Therapy of hypertension disease; - monotherapy; - combined therapy; - adverse reactions; - pharmacoeconomy
2. Therapy of atherosclerosis; - prophylaxis; - antiagregation therapy;
3. Agents used in hyperlipaemia; - algoritms of therapy; - rules of European society of atherosclerosis
4. Ostheoporosis; - prevention; - therapy from the view of its pathomechanism
5. Ostheoporosis; - substitutive therapy; - hormonal therapy
6. Therapy and prophylaxis of nephropathy; - problem from the view of clinical pharmacologist; - new therapeutics methods
7. Therapy of respiratory tract infections
8. Usage of antibiotics for the treatment of respiratory tract infections
9. Therapy of chronic bronchopulmonal disease; - bronchodilators; - inhalation therapy; - monitoring
10. The levels of drug in plasma; - monitoring
11. The drugs and pregnancy
12. Compensatory lessons and credit

Back