All PDF pages will open in a new window.

"The IUPHAR Compendium of Basic Principles for Pharmacological Research in Humans" is the 4th volume in the highly acclaimed series of research compendia published by the International Union of Basic and Clinical Pharmacology (IUPHAR).

The objective of this compendium is to provide the scientific community interested in human research with an easy-to-use guide on how to design a research protocol with humans aiming to assess the effectiveness of a drug in a determined pathological condition or for drug development.

About the Editors

Patrick du Souich, MD, PhD, is a professor and the director of the Department of Pharmacology at the University of Montréal, Canada.

Sergio Erill, PhD, is the director of the Esteve Group, Spain. He has been Professor and Chairman of the Department of Pharmacology at two different Spanish universities, and President of the Spanish Society for Pharmacology.

Michael Orme, PhD, is the former Dean of the Faculty of Medicine at the University of Liverpool, He is also Director of Education and Training for the NW Region of England and President of the European Association for Clinical Pharmacology and Therapeutics, which he helped found in 1983.

"The IUPHAR Compendium of Basic Principles for Pharmacological Research in Humans" is copyright © International Union of Basic and Clinical Pharmacology, 2004. All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, recording or otherwise, without the prior permission of the publishers.

If you want to print the entire compendium, open it from here.

		Page
Acknowledgments		1
About the Authors		2
Table of Contents		3
Introduction		4
Section 1 - Introduction		4
Chapter 1. Ethical Considerations		5
Chapter 2. Good Clinical Practice		11
Chapter 3. Assessment of Endpoints: Kinetics and/or Dynamics		16
Chapter 4. Pharmacogenetics and Pharmacogenomics		27
Chapter 5. Paediatric Drug Research		34
Chapter 6. Phase I (Human Pharmacology)		40
Chapter 7. Follow-Up of Drugs After Market Entry		50
Chapter 8. Bioavailability and Bioequivalence		55
Chapter 9. Pharmacoeconomics and Economic Evaluation of Drug Therapies		67
Chapter 10. Drug Utilization		76
Section 2 - Pharmacological Research in Cardiovascular Disorders		86
Chapter 11. Hypertensive Vascular Disease		87
Chapter 12. Lipid Lowering Agents		106
Chapter 13. Anti-atherosclerotic Drugs		118
Chapter 14. Heart Failure		132
Chapter 15. Arrhythmias		143
Section 3 - Pharmacological Research in Neurologic Disorders		164
Chapter 16. Epilepsies and Convulsive Disorders		165
Chapter 17. Headache Disorders		183
Chapter 18. Alzheimer’s Disease and Other Dementias		212
Chapter 19. Parkinson’s Disease and Other Extrapyramidal Disorders		228
Chapter 20. Multiple Sclerosis and Other Demyelinating Diseases		248
Section 4 - Pharmacological Research in Mental Disorders		263
Chapter 21. Mood Disorders		264
Chapter 22. Anxiety Disorders		272
Chapter 23. Schizophrenic Disorders		278
Chapter 24. Alcoholism and Nicotine Addiction		285
Section 5 - Pharmacological Research in Joint Disorders		293
Chapter 25. Osteoarthritis/arthrosis Short Term Studies		293
Chapter 26. Osteoarthritis/arthrosis Long Term Studies		294
Chapter 27. Rheumatoid Arthritis		308
Section 6 - Pharmacological Research in Other Disorders		337
Chapter 28. Neoplastic Diseases		338
Chapter 29. Analgesic Drugs for Cancer Pain Management		352
Chapter 30. Drugs Used in Osteoporosiss		366